In February of 1940, several members of the church in the Oxford area began meeting in a building located on Choccolocco Street. At that time the building was owned by the Christian church, so the members of the church of Christ would meet in the mornings before the services of the Christian church. The building later became Oxford City Hall.

In April of that same year, a gospel meeting was held with Paul F. Edwards preaching. As a result of that meeting, twelve people were baptized. Soon afterward, about twenty-three families from the area and some from the 16th and Noble congregation in Anniston, began meeting upstairs over the old City Hall and Fire Station on Main Street (approximately where Oxford cleaners is today).

This group of about fifty members then began plans for a new building on Choccolocco Street. The building was completed in June of 1944. It served the congregation well for over 30 years, but due to the growth of the membership, a new building was erected on Hamric Drive. The congregation began worshipping at the new building on September 18, 1977. The building on Choccolocco Street was purchased by the city to house the Oxford City Library.

Over the years that followed, the church at Oxford has been instrumental in helping to establish several congregations. For example, the Logan Martin church of Christ near Pell City and the Montezuma church in Montezuma, Georgia, were started with the help of the church at Oxford. Some initial groundwork was also done in Vienna, Georgia.

In other countries the Lord's work has also prospered through the efforts of the Oxford church. The Roadtown church of Christ in Roadtown, British Virgin Island was established. For over fifteen years a missionary family was sponsored in Cameroon, West Africa. Through this work, under the direction of the elders at the Oxford congregation, many native preachers were trained and numerous churches were started in the villages of Kumba in Cameroon. Since 1995, another missionary family has worked under the direction of the Oxford church on the Caribbean island of Curacao. That work continues to grow.

Our congregational theme for 2008 is "Preach the Word," borrowed from 2 Timothy 4:2-3:

"Preach the word; be instant in season, out of season; reprove, rebuke, exhort with all longsuffering and doctrine. For the time will come when they will not endure sound doctrine; but after their own lusts shall they heap to themselves teachers, having itching ears;"